UNC Systems Biology Literature Page
Systems Biology General
Virtual Lung - CF general Mucus Cilia Biochemical Networks Mucociliary Clearance
Systems Biology General
Books:
1. Foundations of Systems Biology, H. Kitano, Ed., (MIT Press, Cambridge, 2001)
UNC Library- Botany QH313.F66 2001.
Articles:
- Kitano, H., Computational systems biology, Nature 420 (6912), 206-210, 2002. (PDF)
- Kitano, H., Systems biology: A brief overview, Science 295 (5560), 1662-1664, 2002. (PDF)
- Hartwell, L. H., Hopfield, J. J., Leibler, S., and Murray, A. W., From molecular to modular cell biology, Nature 402 (6761), C47-C52, 1999. (PDF)
- Ideker, T., Galitski, T., and Hood, L., A new approach to decoding life: Systems biology, Annual Review of Genomics and Human Genetics 2, 343-372, 2001. (PDF)
- Noble, D., Modeling the Heart--from Genes to Cells to the Whole Organ, Science 295 (5560), 1678-1682, 2002. (PDF)
Virtual Lung
Carolina Alumni Review Article
Kirkham, S., J. K. Sheehan, D. Knight, P. S. Richardson and D. J. Thornton (2002). "Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B." Biochemical Journal 361: 537-546. (PDF)
Bromberg, L. E. and D. P. Barr (2000). "Self-association of mucin." Biomacromolecules 1(3): 325-334. (PDF)
Round, A. N., M. Berry, T. J. McMaster, S. Stoll, D. Gowers, A. P. Corfield and M. J. Miles (2002). "Heterogeneity and persistence length in human ocular mucins." Biophysical Journal 83(3): 1661-1670. (PDF)
Bansil, R., E. Stanley and J. T. LaMont (1995). "Mucin biophysics." Ann Rev Physiol 57: 635-657. (photocopy available upon request)
Molecular Motors: a couple of chapters from Elston
Molecular Motors: Examples Molecular Motors: Theory
Burgess, S. A., M. L. Walker, H. Sakakibara, P. J. Knight and K. Oiwa (2003). "Dynein structure and power strike." Nature 421: 715. (PDF)
Cilia Experiments
Nakano, I., T. Kobayashi, M. Yoshimura and C. Shingyoji (2003). "Central-pair-linked regulation of microtubule sliding by calcium in flagellar axonemes." J. Cell Sci. 116(8): 1627-1638.(PDF)
Chilvers, M. A. and C. O'Callaghan (2000). "Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: comparison with the photomultiplier and photodiode methods." Thorax 55(4): 314-317. (PDF)
Flagella/Cilia Modeling With Models of Motors
Brokaw, C. J. (2002). "Computer simulation of flagellar movement VIII: Coordination of dynein by local curvature control can generate helical bending waves." Cell Motility and the Cytoskeleton 53(2): 103-124. (PDF)
Brokaw, C. J. (1999). "Computer simulation of flagellar movement: VII. conventional but functionally different cross-bridge models for inner and outer arm dyneins can explain the effects of outer arm dynein removal." Cell Motility and the Cytoskeleton 42(2): 134-148. (PDF)
Lindemann, C. B. (2002). "Geometric Clutch model version 3: The role of the inner and outer arm dyneins in the ciliary beat." Cell Motility and the Cytoskeleton 52(4): 242-254. (PDF)
Camalet, S. and F. Julicher (2000). "Generic aspects of axonemal beating." New Journal of Physics 2: 1-23. (PDF)
Continuum Theory/Hydrodynamic Coupling
Gueron, S. and K. Levit-Gurevich (1999). "Energetic considerations of ciliary beating and the advantage of metachronal coordination." Proceedings of the National Academy of Sciences of the United States of America 96(22): 12240-12245. (PDF)
Gueron, S. and K. Levit-Gurevich (1998). "Computation of the internal forces in cilia: Application to ciliary motion, the effects of viscosity, and cilia interactions." Biophysical Journal 74(4): 1658-1676. (PDF)
Sleigh, M. A., J. R. Blake and N. Liron (1988). "The Propulsion of Mucus by Cilia." American Review of Respiratory Disease 137(3): 726-741. (photocopy available upon request)
Blake, J. R. (2001). "Microbiological fluid mechanics: a tribute to Sir James Lighthill." Mathematical Methods in the Applied Sciences 24(17-18): 1469-1483. (PDF)
Dillon, R. H. and L. J. Fauci (2000). "An Integrative Model of Internal Axoneme Mechanics and External Fluid Dynamics in Ciliary Beating." J. Theor. Biol. 207: 415-430. (PDF)
Biochemical Networks in Mucociliary Clearance
Morse, D. M., J. L. Smullen and C. W. Davis (2001). "Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells." American Journal of Physiology-Cell Physiology 280(6): C1485-C1497. (PDF)
Lansley, A. B. and M. J. Sanderson (1999). "Regulation of airway ciliary activity by Ca2+: Simultaneous measurement of beat frequency and intracellular Ca2+." Biophysical Journal 77(1): 629-638. (PDF)
Berridge, M. J., P. Lipp and M. D. Bootman (2000). "The versatility and universality of calcium signalling." Nature Reviews Molecular Cell Biology 1(1): 11-21.(PDF)
Books:
Matsui, H., S. H. Randell, S. W. Peretti, C. W. Davis and R. C. Boucher (1998). "Coordinated clearance of periciliary liquid and mucus from airway surfaces." Journal of Clinical Investigation 102(6): 1125-1131. (PDF)